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We found that criteria for clinical trial eligibility are frequently under-reported in medical communications.
Incorporating standardized comorbidity measurement, relaxing clinical trial eligibility criteria, and utilizing novel trial designs are critical to developing a larger and more generalizable evidence base to guide the management of these patients.
We aimed to determine whether a prospective TB is an effective strategy for trial recruitment and to identify steps within the TB process that facilitate discussion of trial eligibility and optimize accrual.
Two authors independently assessed trial eligibility and quality.
One reviewer (IS) assessed trial eligibility, under the supervision of the senior authors (PRW and RLS).
Two reviewers determined the trial eligibility independently.
Trial eligibility is checked and written informed consent is obtained.
Two independent reviewers (JCP and SCF) decided trial eligibility.
Two investigators (MV and GF) independently assessed trial eligibility.
First and foremost, the trial eligibility criteria varied significantly between the two reviews.
Two authors independently assessed trial eligibility and risk of bias, and extracted data.
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