Exact(1)
In contrast, group-sequential trial designs are hallmarked by predefinition of number, time points, and stopping rules of interim analyses to enable the trial to be terminated early due to either fertility or futility should the trial develop against former expectations.
Similar(59)
Subjects in that trial developed a higher incidence of H.I.V. infection, presumably through ulcers caused by chemical irritation.
Griffith-Jones's assumptions about society reflected his station in it, and as the trial developed he seemed more scandalised by adultery – especially with a servant – than by the four-letter words that had preoccupied him at the start.
As the trial developed, Mrs Brooks's and Coulson's defence case became clear.
Like other authors [79], we consider that the concept of an "ICU trial," developed and studied in the adult population [80], can be adapted to the pediatric population.
The STEP vaccine trial developed by Merck used a replication-defective Ad5 vector, expressing Gag, Pol and Nef proteins from HIV-1 [2].
NEF and EMH conceived of the trial, developed the trial design and secured funding.
No subject in the trial developed grade 3 or 4 haematological toxicity.
No patient in the trial developed tumour-related pain requiring treatment with opioid drugs.
One patient receiving oral vancomycin in a phase 3 trial developed torsades de pointes.
Indeed, only one patient on the present breast cancer trial developed greater than a grade 1 liver enzyme elevation.
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