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42 The CONQUER trial demonstrated significant improvements in relation to glycemic profiles.
The trial demonstrated significant decreases (-7.2%) in the percentage fat free mass in the control group with no decreases in the intervention group.
The PLATO trial demonstrated significant reductions in the composite endpoint of cardiovascular death, MI, and stroke over a 1-year period with the use of ticagrelor versus clopidogrel in the treatment of ACS patients.
The Cancer and Leukemia Group B (CALGB) 8433 trial demonstrated significant improvements in the combined modality therapy group, with a longer median survival time (13.7 months vs. 9.6 months; p = 0.012) and higher 5-year survival rate of 17% versus 6% [ 7].
At the end of a 6-month follow-up period, participants in The Weight Loss Maintenance trial demonstrated significant weight loss across racial and gender groups; weight loss was greatest among non-African American men and least among African American women [ 55].
A randomized, open, placebo-controlled trial demonstrated significant efficacy of doxycycline (200 mg orally once a day for 28 days) in combination with gentamycin (3 mg/kg intravenously once a day for 14 days) in homeless persons with B. quintana chronic bacteremia (38 ).
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The trials demonstrated significant reductions of up to 0.5 log10 in plasma viral load and up to 0.3 log10 in genital HIV load among HIV-HSV-2 coinfected persons during HSV-2 suppression [46], [47], [48], [49], [50], [51].
Subgroup analysis of these trials demonstrated significant mortality and morbidity benefits in diabetic patients.
One of these trials demonstrated significant effects of scalp acupuncture on symptom relief [ 12, 15], but the other trial failed to significantly reduce OAE [ 12, 15].
All of these trials demonstrated significant reductions in late lumen loss at 6 months and lower rates of target lesion revascularization at 1 year for DCB versus PTA.
A contemporary meta-analysis of randomized controlled trials demonstrated significant short and long term improvements associated with inpatient geriatric rehabilitation related to functional status, admission to nursing homes and mortality [ 1].
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