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This randomized clinical trial demonstrated a therapeutic benefit of treating patients with advanced melanoma with oncolytic HSV encoding GM-CSF; these data led to regulatory approval of this treatment in the USA, Europe and Australia.
Results from the initial trial demonstrated a considerable improvement over the conventional TOA source location method, with a reduction in location error from 4.81% using the conventional TOA technique, to 1.77% using "Delta T" location.
An in vivo therapeutic tumor trial demonstrated a superior survival rate of 9/10 for mice vaccinated with HYN-SS conjugate compared to HYN (6/10), SS (2/10), and the mixture (2/10).
This pilot trial demonstrated a significant therapeutic effect with intranasal evaporative cooling as an acute treatment for migraine.
The Dutch Phase III pelvic tumor trial demonstrated a survival and local control benefit due to the addition of hyperthermia (HT) to RT.
The SMART randomized trial demonstrated a statistically significant higher 30-day in-hospital mortality in septic patients treated with saline compared to those treated with balanced crystalloids [49].
The EVAR-1 trial demonstrated a significant reduction in 30-day post-operative morbidity and mortality in patients undergoing EVAR compared with open aneurysm repair [1, 3].
Otherwise, the secondary endpoints that were analyzed in addition to the reduction of migraine days in this trial demonstrated a statistically significant benefit of the triple combination compared to placebo.
Interestingly, this second trial demonstrated a survival benefit in critically ill trauma patients randomized to receive EPO treatment: at day 29 (deaths: placebo 8.9% vs. EPO 4.1%) and day 42 (deaths: placebo 10.4% vs. EPO 4.8%).
A recent trial demonstrated a significant improvement in survival in patients ventilated with low (LVT) compared to high tidal volumes (HVT) [5].
This trial demonstrated a benefit in immune-related progression-free survival, defined later in this review.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com