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CONCLUSIONS: An indirect comparison of new anticoagulants based on existing trial data indicates that in patients with a CHADS(2) score >/=3 dabigatran 150 mg, apixaban 5 mg, and rivaroxaban 20 mg resulted in statistically similar rates of stroke and systemic embolism, but apixaban had a lower risk of major hemorrhage compared with dabigatran and rivaroxaban.
A pooled analysis of clinical trial data indicates they reduce mortality by ~25% relative to placebo over three to four years of follow-up [ 12].
However, a meta-analysis of systematic reviews of clinical trial data indicates that TCZ, TNF inhibitors, and abatacept have similar efficacy in combination with MTX [ 76].
When used at its therapeutic dose (1.5-9 mg of cytisine per day) trial data indicates that Tabex® is well tolerated with few adverse effects, similar to those seen with NRT use [ 14- 17].
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"These are the first randomized trial data indicating a possible benefit," he said.
The cumulated randomized controlled trial data indicate that after 4 to 6 years of use, hormone therapy reduces coronary heart disease risk relative to placebo in women with or without pre-existing coronary heart disease.
The pharmaceutical colossus is voluntarily yanking its blockbuster arthritis drug Vioxx from the global market after new clinical trial data indicated an increased risk of heart attack and stroke.
The trial data indicated that the intervention is effective at helping people manage their fatigue.
There are substantial trial data indicating fairly predictable lipid-modifying efficacy for each statin.
Risk assessments for CoQ10 based on various clinical trial data indicate that the observed safety level for CoQ10 in humans is between 900 and 1200 mg/d/person.
Most recently, clinical trial data indicated one-legged stance improvement with Tai Chi and yoga exercises with mindfulness modified for FM [ 44, 45].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com