The in situ trial consisted in the incubation of the differently treated barley grains (i.e., CON, LA, LAH) up to 48 h in the rumen of cows fed diets containing the respective barleys.
Each trial consisted in the presentation of a 300 ms search array including (S1) or not including (S2) a target, followed by a variable inter-trial interval (ITI) of 900, 1200 or 1500 ms (Figure 1A).
After the dual tasks, participants had to perform a graphomotor task One trial consisted in tracing three shapes, a circle, an oval and a stroke, oriented at 1∶30 on a digitizing tablet (Wacom Intuos 3 a3).
Each trial consisted in the repeated presentation (six times) of two images, with an interleaved blank screen.
Each trial consisted in the repeated presentation of two pictures, with an interleaved blank image (Fig. 1A).
Usual methodology of cancer phase II trials consists in testing the null hypothesis Π≤ Π0versus Π≥ Π1 = Π0 + δ, where Π0 is the highest probability of response which would indicate that the agent is of no further interest, and Π1the smallest probability of response indicating that the agent may be promising.
These encouraging results lead to the second step of these trials consisting in treating younger patients.
Traditional phase 1 oncology trials consist in the administration of increasing doses of the experimental compound to successive cohorts of patients until the maximal tolerated dose is reached.
Such trials consist in a design where successive cohorts of patients are treated with increasing doses of the drug.
The analysed trials consisted in nutritional treatment and were carried out on healthy subjects in order to test the effect of either two types of food (meat v. soya), or certain nutrients (quantity of protein or dairy protein v. soya protein), or even acidifying (NH4Cl) or alkalinising (citrate, sodium bicarbonate or K) salt supplements.
