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The analyses presented here focus on the binary choice data obtained during training and test trials: the test trial confidence data are not considered for the present purposes.
Of note is that the trial confidence interval did include the systematic review's overall estimate in 25 of the 31 cases, and the confidence intervals overlapped in all but 1 case.
Our effect size is towards the conservative end of our platform trial confidence interval [ 19] SMD: 0.63; 95% CI 0.18 to 1.07, an effect size achieved by Pilling et al [ 22] SMD 0.42; 95% CI -0.05 to +0.89, and in line with the findings of recent reviews [ 23] and our group's recent meta regression [ 14].
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It is possible to quantify metacognitive accuracy in a particular domain by measuring the fidelity of subjects' trial-by-trial confidence judgements with respect to objective task performance (Clarke et al., 1959; Weiskrantz, 1998; Galvin et al., 2003; Maniscalco and Lau, 2012).
Methods/Assessment of heterogeneity - we have added the following text: "We have left the overall totals turned off only if the effect estimates of different trials were so disparate that it made little clinical sense to combine the trials (for example, if effect estimates fell on opposite sides of the line of no difference and the trials' confidence intervals do not overlap).
We have left the overall totals turned off only if the effect estimates of different trials were so disparate that it made little clinical sense to combine the trials (for example, if effect estimates fell on opposite sides of the line of no difference and the trials' confidence intervals do not overlap).
When available, the original trial data confidence intervals were used, as for the PE.
However, we were appropriately powered to detect the large effects observed in the trial, as confidence intervals around the primary outcomes were precise.
PID, pelvic inflammatory disease; RCT, randomised controlled trial; CI, confidence interval.
As this was an equivalence trial, a confidence interval (CI) approach was used (Jones et al, 1996).
As more patients entered the trial, the confidence interval narrows, and widens again as the patient population at risk declines due to disease-free events and censoring.
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