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Nevertheless, they agreed to a trial closure for a few months in 2004.
Insufficient accrual was the most common reason provided for trial closure (n = 23, 25.3%).
Announcing the six-month trial closure, Paris's police prefect, Michel Cadot, said he would be watching closely its impact on traffic and pollution, and warned the highway would be reopened if it caused "a major traffic problem".
There is quite a lot of tension around, people saying 'why are you doing this for cyclists?'" The two week trial closure, which runs until 13 October, has sparked lively discussion both locally and nationally (featured on Radio 4's Today Programme), but, Gasson says: "We have seen the worst of it, I think.
There is growing concern that a trial closure of a junction on the M4 at Port Talbot could harm the local economy.
An ongoing trial (CLOSURE 1) is comparing the use of a percutaneously placed PFO occlusive device and best medical therapy versus best medical therapy alone for prevention of recurrent ischaemic neurological symptoms among persons with TIA or ischaemic stroke [39].
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A major complaint has been a perceived lack of information from the council ahead of the trial closures.
We included media reports addressing the trial closures, the reasons for the trial closures, and who was interviewed.
The absence of clear communication between trial participants and trial investigators contributed to premature trial closures in at least two sites [ 1, 2].
With worldwide media attention, these trial closures demonstrate the ability of activists to engage the media and bring about important consequences for the conduct of trials.
Communication was an important theme: the absence of clear communication between trial participants and investigators contributed to premature trial closures in at least two sites.
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