But Dr. Blanke and Dr. Allan T. van Oosterom of the University of Leuven in Belgium, who led a smaller European trial, cautioned doctors and patients not to do so.
After Gideon Hausner, the prosecutor in the Eichmann trial, cautioned that publication of the memoirs could compete with the verdict, Prime Minister David Ben-Guriorderedred the manuscript locked away for 15 years at which time that decision was to be reconsidered.
Nissen, a busy man who is also running a Lipitor combo-pill trial, cautions that Pfizer's approach could conceivably produce HDL particles that are different from normal, diminishing their therapeutic effect.
Because patients with internal malignancies and melanoma were excluded from the trials, caution should be exercised when considering the use of efalizumab in patients at high risk for malignancy or with a history of malignancy.
On Monday, the F.D.A. said doctors "must interpret the results of the Jupiter trial with caution".
In summary, each study represented a singular trial and caution is called for in interpreting the results of the studies as further research is likely to change the impact of confidence.
However, because this population consisted of patients selected with criteria typical of clinical trials, some caution is needed in generalizing the study's findings.
Despite the 89% efficacy rate found in the trial, they cautioned against the "danger of giving [the numbers] too much weight in the face of the relatively small number of whooping cough cases" (14 ).
If subjects erroneously made a response, they received a penalty of equal value to the bonus during successful trials (100 points in baseline trials; 200 points in caution trials).
"These are still small trials," Heuser cautions.
