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Investigators in the Netherlands will soon conclude their randomized, placebo-controlled clinical trial (CAPITA) of PCV13 vaccination in 85 000 community-dwelling persons ≥65 y of age.
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The Ohio State University is among the country's top public research institutions at #7. Ohio is ranked in the top eight for states conducting clinical trials, including conducting the most clinical trials per capita.
To determine the accurateness of detecting community-acquired pneumonia (CAP) in the Community-Acquired Pneumonia immunization Trial in Adults (CAPiTA), a community-based, double-blind, randomized placebo-controlled trial in which the needed to treat (NNT) for prevention of vaccine-type pneumococcal CAP was 1,007 [95% confidence interval (CI): 613, 2,646].
There is a good possibility that the CAPITA trial results will be inconclusive.
These effects stretch beyond the hospitalization period, as covered in the CAPiTA trial.
As part of the CAPiTA trial, patients with a clinical suspicion of CAP are tracked in 56 Dutch sentinel hospitals.
At this time, we cannot know whether the CAPITA trial will yield useful results, but there are reasons for doubt.
The Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA) trial should provide more definitive data on the role of adult PCV13 vaccination in preventing vaccine-serotype-specific pneumococcal community-acquired pneumonia (CAP).
Within the CAPiTA trial, 84,496 volunteers aged 65 and over, dispersed over the Netherlands, received 13vPnC or placebo in a single-dose vaccine between October 2008 and 31 January 2010.
The infrastructure of the CAPiTA trial offers a unique opportunity for prospective collection of health outcomes, QoL and cost data of patients hospitalized with CAP.
The efficacy of the PCV-13 in the elderly has been investigated according to these requirements in a large RCT known as the CAPiTA trial [ 12, 13].
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