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We urge Dr Lestuzzi et al to conduct a phase III trial based on their rationale for intrapericardial platinum.
It recommends to the sponsor whether to continue, modify, or stop the trial based on their assessment of the data.
For example, the values of trust and honesty may be more significant to participants who are willing to enter a trial based on their physicians' recommendations.
They were stratified into one of 3 groups (positive outcome, no change, worse outcome) as they completed the final 6 month assessment of the trial, based on their scores on questionnaires used to assess the outcomes of the RCT.
Thirty rural villages were selected for inclusion into the trial based on their history of not having previous experience with economic empowerment programming and their status as being a priority area for intervention by IRC, the implementing agency.
It has been suggested that patients can be initially motivated towards participating in a trial based on their willingness to help others or to help research in general; however, this would be heavily influenced by whether there is a potential personal benefit in participating in that particular RCT; this is known as "conditional altruism" [ 37].
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Martha Karolyi, the women's national team coordinator, also invited seven other gymnasts to the trials based on their strengths in individual events.
Elderly patients have been under-represented in breast cancer treatment trials, based on their age, comorbid diseases, and logistic barriers [ 2, 6].
Clinicians may hesitate to inform patients of trials, based on their own attitudes and beliefs about a patient's willingness to participate, ability to understand the trial, or adhere to the protocol (EDICT, 2008).
Several Rapamycin-like drugs have been introduced into clinical trials based on their potential antitumor effects [ 6- 8, 12, 13]; however, the role of immune suppression inherent to these agents as related to their anticancer activity has not been addressed.
To test the latter hypothesis, we sorted the trials based on their date of the last activity to investigate whether the predictive quality varies with this timestamp, see Figure 2. The values of both MCC and AUC are lower for the more recent trials for majority of the methods, except for the PPCpred, XtalPred and the BLAST-based predictor.
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CEO of Professional Science Editing for Scientists @ prosciediting.com