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Accrual by age, in 2-year intervals is shown in Figure 4 together with trial availability and age eligibility criteria.
Further study is required to identify trends in trial availability and accrual for those tumours constituting the remaining 26% of TYA cancers.
Further research is required to identify trends in trial availability and accrual for those tumours constituting the remaining 26% of TYA cancers.
We determined the clinical trial availability by manually searching each trial summary to select study type; study design; eligibility criteria and current recruitment status.
Closer dialogue between those involved in planning and running trials for children and for adults is necessary to improve trial availability and recruitment.
Lack of trial availability or open cohorts prevented 8.4% of newly referred, eligible and interested patients in our study from participating in a trial.
Similar(52)
Part way through the trial, the availability of ARV medication increased and mothers and children in the study were screened for ARV eligibility and treated according to Tanzanian Ministry of Health guidelines.
The large size of the trial and availability of data for many patients on a range of health and lifestyle factors as well as sociodemographic factors enabled us to undertake these analyses.
Further strengths were: (1) the systematic follow-up available through cancer registries and/or data from clinical trials; (2) availability of information to adjust for prognostic risk group; and (3) extended cumulative follow-up including the interval where risk of relapse and/or death is greatest.
Since structural damage outcomes require lengthy clinical trials, the availability of biomarkers associated with these long-term endpoints would be an attractive therapeutic development strategy, especially in early phase trials when decisions are being made whether and how to proceed with pivotal clinical trials.
It is likely to become more commonly used after the results of larger trials and availability of equipment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com