In the short term, as confirmed by the recent trials, attaining glucose targets by diet, exercise, or drugs would decrease adverse outcome in index pregnancy.
The infusion masking will only be removed in cases of a serious adverse event or when the primary endpoint of the trial is attained.
It is assumed that, at 24 months post randomization, all surviving trial patients attained the same average life expectancy and health state as adults of similar age in the UK population.
Highest accuracies (89% correctly classified trials) were attained when classifying object drawings.
The net health benefit acceptability curve shows the proportion of trials that attained cost-effectiveness for a given strategy for willingness-to-pay thresholds up to $200,000/QALY.
Both trials have attained the primary endpoint of >35% reduction in spleen size, as measured by imaging techniques, at 24 or 48 weeks of treatment start, respectively, and, based on these results, application for the drug approval is currently in progress.
31– 33 In a post hoc analysis of the JUPITER trial, those attaining an LDL-C <50 mg/dL (∼1.3 mmol/L) were more likely to be male, white, and to have impaired fasting glucose than those with higher LDL-C levels.
A combined concordance score of 90% (p<0.0001, binomial test) was attained in training trials on laboratory diet (termed Diet L).
Data were initially summarized as the number of trials to attain 80% criterion on a single test day.
11 There is as yet no sense of a level playing field for evaluation, so the criterion of equipoise, required for a randomised trial, is not attained.
