It challenges racism, but also liberal assumptions about cultural identity.
The researchers who conducted the interviews were not known to them and they were therefore able to freely express their honest views and opinions without fear of offending the people who had supported them during the trial, and without assumptions about views and experiences already expressed in previous meetings with trial personnel.
However, determination of the number of patients that have to be recruited to observe the calculated number of events requires specification of the length of the accrual period, the trial duration and assumptions about the event-specific hazard functions.
Third, the clinician may make decisions, either consciously or sub-consciously, about the appropriateness of referral for a trial based on assumptions about their socioeconomic characteristics.
To simulate outcomes in the period after the trial, we made assumptions about the costs, diabetes relapse rate, and mortality rate for patients in remission from diabetes.
As our assumptions about trial quality are dependent on the overall quality of the reporting in the articles describing the trials, we included a variable to indicate whether a flow diagram recommended by CONSORT was included in the report [19].
By using actual trial data, we reduced assumptions about prognosis and resource utilisation that are often required in economic analyses.
Certainly, like many of us facing our own trials, some the Sullivans' assumptions about life were upended after their son's death.
The designer of a clinical trial needs to make many assumptions about real-life practice based on prior knowledge.
We used published data and assumptions from the POPI trial to: investigate how different assumptions about the temporal relationship between chlamydia infection and the development of PID can influence the sample size calculation; and to investigate how a mathematical model can be used to inform sample size calculations for an RCT.
