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This method is aligned to the Diabetes Control and Complications Trial assay.
Both instruments were standardized to the Diabetes Control and Complications Trial assay (16).
HbA1c measurements were obtained using high-performance liquid chromatography standardized to the Diabetes Control and Complication Trial assay (20).
It appears likely that trial assay sensitivity is reduced with variable penetration depending on the specific therapeutic circumstances of the individual study.
Importantly, however, the HbA1c assay at all study points in time was calibrated to the Diabetes Control and Complications Trial assay.
The A1C was measured using a Tina-quant II immunoassay method (Roche Diagnostics, Basel, Switzerland) and calibrated to the Diabetes Control and Complications Trial assay.
Similar(46)
The HVTN PBMC Quality Management Program is designed to ensure that viable PBMC are processed, stored and shipped for clinical trial assays from all HVTN clinical trial sites.
This is difficult and needs to be overcome by trial assays.
In the ACCENT I trial as well as in the ACCENT II trial, assays used for the measurement of ATIs were not described in the text.
In the case of controlled clinical trials, assay sensitivity is achieved through careful selection of study sample, design, and assessment instruments.
In the case of two days of active place avoidance, the first trial of the second day (the 7th trial of 12 total trials) assayed 24-hour memory retention of the shock zone location.
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