Adjusting the viscosity of the displacing liquid, maintaining the same concentration of chemicals in the slug, the same slug size and relative permeability curves as resulted from the experimental data was the first trial, as presented in Fig. 2.
This was confirmed in the present trial, as presented in the initial report [22], and in a study of RTS,S/AS01E administered to infants together with EPI vaccines [15].
As stated before, the lung cancer trial as presented in the earlier paper is an example of scenario (a).
Similarly, mutation frequencies in the ER gene (ESR1) differ between primary and metastatic tumors, as seen through large-scale next-generation sequencing of postmenopausal women with ER + metastatic breast cancer treated with everolimus in combination with exemestane within the BOLERO-2 trial, as presented by Dr Piccart at the 2013 IMPAKT meeting (unpublished observations, Martine Piccart).
Correlation of additive, nonadditive, and total genetic affects across trials, as presented by Beeck et al. (2010) and Cullis et al. (2010), is equivalent to correlation across selection cycles in our model.
General knowledge about clinical trials, as presented in the DA, was assessed using an adapted form of an existing 7-item scale used in the IBIS-II DCIS DA pilot (Juraskova et al, 2007, 2008).
Several secondary outcomes were also assessed: Participants' knowledge about clinical trials generally and the IBIS-II trial specifically was assessed using the following scales: General knowledge about clinical trials, as presented in the DA, was assessed using an adapted form of an existing 7-item scale used in the IBIS-II DCIS DA pilot (Juraskova et al, 2007, 2008 ).
Therefore, the trial design as presented will provide important insights in various strategies for treatment of dyspepsia in primary care.
The recruitment intentions and the trial protocol as presented here are essentially as written in the manuscript prepared in 1994 with the full intention of publishing the trial (Northover and Houghton, 1994, unpublished work).
For detailed information on the sample size, randomization, allocation concealment, method for data collection and detailed descriptions on the interventions provided we refer to our study protocol and the CONSORT Checklist of items of cluster randomized trials[ 23], as presented in Table 1.
On the basis of this consideration, partial-road-in backfilling is highly proposed to realize a compromising intention, and in order to obtain the exact value of ∆h in Fig. 6b, we conducted a field trial in Xieqiao Mine, as presented in the next section.
