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We conducted a single-center, double-blinded, randomized clinical trial as a substudy of "Efficacy and safety of pitavastatin and atorvastatin: a 12-week, randomized, double-blinded, active controlled study in high risk patients with hyperlipidemia" (registered at ClinicalTrials.gov, NCT01386853).
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The SECURE trial was designed as a substudy of the HOPE trial to evaluate the effects of long-term treatment with ramipril and vitamin E on atherosclerosis progression in high-risk patients.
This randomized controlled trial was a substudy of a Nordic multicenter study.
All children admitted to the ARCADE cohort were eligible for participating in the trial, which was carried out as a substudy of ARCADE.
It was planned as a substudy of a clinical trial with the aim of analysing the impact of haemolysis during CPB.
As a substudy of the HF-ACTION trial, 398 subjects (73% men, 27% women; mean age 59 years) with heart failure and left ventricular ejection fraction ≤35% underwent 2 baseline cardiopulmonary exercise tests within 14 days.
As a substudy of the HF-ACTION trial, 398 subjects (73% men, 27% women; mean age 59 years) with heart failure and left ventricular ejection fraction < or =35% underwent 2 baseline cardiopulmonary exercise tests within 14 days.
As a substudy of a larger pragmatic trial, the findings are important for three reasons; first, the emphasis on external validity with findings that are generalisable to primary care patients with depression across the UK.
We performed a prospective observational study in the UMC Utrecht, as a substudy of the Optica study.
As a substudy of HUBRO, bone mineral density and vitamin D status were measured in the period May 2000 to January 2001.
Overall, the Brief Report has served Diabetes Care well as it allowed publication of very concise and important findings, generally as part of an independent study, or a relevant finding as part of a substudy of a major trial.
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