TGR & GAF were co-investigators responsible for developing the trial, applying for trial funding and were members of the trial steering committee.
Consequently, between 2007 and 2011, the number of clinical trials conducted in the EU fell by 25%%, and the number of clinical trials applied for in 2007 50000) dropped to 3800 by 2011, with most studies being limited to one country.
Three percent SPL 7013, the concentration used in this clinical trial, applied vaginally to pigtailed macaques for four consecutive days did not lead to cervicovaginal tissue disruption and/or friability in any of six animals, while 5% SPL 7013 led to tissue disruption and/or friability in four of six animals [9].
Distributions of patients from the CAPRA-1 trial were applied for the first 3 months for treatment with MR-prednisone.
Distributions of patients from the CAPRA-1 trial were applied for the first 3 months of treatment; following this, the mean change from 0 to 3 months was applied between months 3 and 6.
However, to avoid a learning effect across days of testing it is recommended that habitation trials are applied for both young and old adults when testing RT in the lower extremities.
Only 3 (6%) of the reviewed prophylactic trials applied stratification for migraine attack frequency.
In the previous GeparQuattro trial applying only trastuzumab for HER2-positive patients, we observed that elevated sHER2 levels before and a decrease of >20% during NT (measured before and after NT) were associated with pCR (Witzel et al, 2010).
Trial registration Current Controlled Trials ISRCTN46035546 We initially applied for a substantial amendment on the 5th of September 2011 to change the study design from individually randomised to cluster randomisation of patients by physiotherapists.
The authors GP, JE, OS, MJH and KW developed the trial outline, protocols and applied for ethics committee approval.
