**There was a significant interaction between superiority/noninferiority type of the trial and sample size.
First, this study was a non-randomized controlled trial and sample size for each dye was rather small.
Meta regression ("metareg" command) was performed to investigate the association between weight change and trial and sample characteristics that were designated a priori.
The purpose of this study is to conduct a systematic review and meta-regression of behavioural weight loss interventions to quantify control group weight change, and relate the size of this effect to specific trial and sample characteristics.
The first objective of this study is to systematically review the behavioural weight loss intervention literature in order to describe the associations between control group weight change and specific trial and sample characteristics.
The second objective is to conduct a meta-analysis to quantify the amount of weight change that occurs only in control groups, and a meta-regression analysis to relate the size of this effect to specific trial and sample characteristics.
Other designs (cluster trials) and sampling plans with longer follow-up should be considered when planning future studies of education outreach programs in this setting.
The trial design and sampling protocol is shown in Fig. 1.
Section Special Topics in Trial Design considers special topics for study design, including interim monitoring, alpha spending, adaptive designs, equivalence and noninferiority trials, and sample size.
Python (python.org) and the Pygame (pygame.org) video game module were used to present training trials and sample the Wiimote-controlled cursor movements as streaming x-y coordinates.
