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A participant death is a serious event in a clinical trial and needs to be unambiguously and publicly reported.
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At the same time, this observation has clear implications in clinical trial design and needs to be accounted for.
All these hypotheses and the deduced mathematical models have to be tested in prospective clinical trials and need to be confirmed in a population based cohort.
This is especially relevant for interventions in aging, which cannot be tested easily in clinical trials and need to be applied over extended periods of time.
The investigational protocol arm comprised those failed to respond to sequential therapeutic trials and needed specific investigations to establish a diagnosis.
New RA remission criteria were developed by the American College of Rheumatology (ACR)/EULAR in 2011 on the basis of using data from four clinical trials and need to be validated using different datasets in clinical practice [ 11].
Please contact with a description of your research project or clinical trial and support needs.
Compound subjects ("trial and retrial") need a plural verb: "have attracted," not "has".
Our era may be losing the tolerance for the trial and error needed to make innovations successful.
As this task is mostly performed by trial-and-error, the need arises for algorithms to perform this task in a clever way.
Reasons for lack of uptake include cancer planners' anticipation of a misfit between interventions tested in controlled efficacy trials and the needs of their settings [ 8– 10].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com