The mixed reality design trial allows for rapid prototyping in a virtual environment, instead of having to create new physical models to see what new materials and angles will look like on a final design.
In fact, the ethical guidelines issued by the Council for International Organizations of Medical Sciences, in its chapter on animal experiments emphasize that the validity of a trial allows for using the minimum number of animals in an experiment.
The crossover trial allows for a within-patient comparison between treatments because each patient serves as his or her own control subject, removes the interpatient variability from the comparison between treatments, and can provide unbiased estimates for the differences between treatments.
The higher cost of a mock trial allows for a more realistic portrayal of the real trial and (researchers hope) more accurate data.
The factorial design of the trial allows for the main effects and interactions between interventions to be examined.
A cluster randomized controlled trial allows for statistical analysis of the feasibility and effectiveness of an intervention on care provision.
The trial allows for a detailed assessment of the costs associated with the care of the neonate from the two different care strategies.
The depth of information collected from participants in the ProAge trial allows for more complex modelling of factors associated with self-reported vision loss (unrelated to known eye disease) and use of eye screening services than previously carried out.
