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The study was run as parallel trial, adopting a randomisation ratio between arms of 1 : 1.
For instance, in cases with a MR2 profile, further intensification of chemotherapy is not expected to be effective, given the saturation of the MRD response already observed at week 16 in a large German trial adopting a very intensive schedule.
As far as we know, this is the first acupuncture trial adopting sham EA combined with mosapride (MS) as a control to observe the efficacy of acupuncture for treating FC.
It seems appropriate, therefore, to conduct a larger scale trial adopting a similar approach to Norell et al. with longer follow-up, and detailed reporting of research methodology to demonstrate research rigour.
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This trial adopts the double-blind method.
The rEECur trial adopts an adaptive multi-arm design with forced selection at a series of pre-specified interim analyses.
Commonly, a nurse or physiotherapist who has been through a training program related to the trial, adopts this role.
This trial adopted a two-stage Gehan design (Gehan, 1979), enrolling 14 patients in the first stage.
One trial adopted a cross-over RCT design (full details of included studies are in Table 2).
The trial adopted various recruitment and matching procedures in an attempt to prevent or limit the potential for major imbalances between groups [ 46].
To overcome this limitation and ensure this trial adopts a fully intention-to-treat design, multiple imputation will be performed for participants with only baseline-data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com