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This trial adopted a two-stage Gehan design (Gehan, 1979), enrolling 14 patients in the first stage.
One trial adopted a cross-over RCT design (full details of included studies are in Table 2).
The trial adopted various recruitment and matching procedures in an attempt to prevent or limit the potential for major imbalances between groups [ 46].
The trial adopted a pragmatic approach in which the intervention was introduced into practice systems remotely, in the same way in which it might be rolled-out into routine practice.
On one hand, this trial adopted oral care protocols without chlorhexidine; on the other hand, the small number of cases and participants increased the possibility that chance accounted for the results.
36, 38 Since PCI is often performed within this timeframe, the ESPRIT (Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy) trial adopted a regimen that included a second bolus dose (administered within affinity. 10 min of the first) to ensure adequate inhibition of platelet aggregation during PCI.
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This trial adopts the double-blind method.
The study was run as parallel trial, adopting a randomisation ratio between arms of 1 : 1.
The rEECur trial adopts an adaptive multi-arm design with forced selection at a series of pre-specified interim analyses.
Commonly, a nurse or physiotherapist who has been through a training program related to the trial, adopts this role.
To overcome this limitation and ensure this trial adopts a fully intention-to-treat design, multiple imputation will be performed for participants with only baseline-data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com