Logistic regression evaluated characteristics associated with intent to participate in an influenza vaccine trial, adjusted for age, gender, language, and education history.
For women aged 44 to 49, ONS incidence rates are affected by screening at age 49; we therefore used the incidence in the control arm of the Age trial, adjusted by the ratio of the ONS rates to Age trial rates for the 40 to 44 age group.
One trial adjusted for clustering by comparing the mean incidence rate of intervention and non-intervention classrooms (Kotch 1989 USA), but only a cluster-adjusted 95% CIs for a different outcome (excess mean episodes) and not a rate ratio was presented.
First, as pointed out in the introduction, Sogo and Osaka's data may underestimate or overestimate the degree of horizontal compression depending on the particular task strategy participants choose on any given trial – adjusting the length of the probe to the length of remembered figure or adjusting the length of the probe so that the probe matches the shape of the remembered figure.
If appropriate, and depending on the distribution of the continuous outcome measures, a linear mixed-effects model will be used to analyse SGRQ-C over the 12-month period of the trial, adjusting for baseline value and minimisation covariates.
Somewhat surprisingly, there was a modest fourth-order polynomial fit to the motion data (t[95] = 2.33, p = .025, adjusted R 2 = .16), but this did not survive cross-validation in either the training trials (adjusted R 2 = .15) or the test trials (adjusted R 2 < 0).
The corrected chronological age refers to the age at the start of administration (as reported in two pivotal trials) adjusted to reflect the gestational age at the birth; for example, an infant who is 20 weeks old at the start of administration but was born at 30 wGA would have a corrected age of 10 weeks, assuming a typical 40-week gestation.
Most trials that balanced on centre or prognostic factors were not adequately analysed; only 26% of trials adjusted for all balancing factors in their primary analysis.
All trials adjusted for clustering in some way, except for Han 1985 MMR, Langford 2007 NPL, Nicholson 2008 IND, and Hartinger 2010 PER.
These were trialed, adjusted as required, and then embedded into routine clinical practice as a new multidisciplinary, multimodal nutritional model of care.
In a first step, the predictive value of the BiomarCaRE panel will be assessed in samples from the clinical trials, adjusted for medication and stratified by intervention group.
