In the SAVOR trial, adjudication-confirmed cases of pancreatitis occurred in a similar proportion of patients receiving saxagliptin (0.29%) or placebo [0.26%; HR (95% CI) 1.13 (0.63, 2.06); P = 0.77] [ 64].
For instance, in orthopaedic surgery fracture trials, Adjudication Committees may serve a useful function in the assessment of fracture healing.
You're going through a pre-trial adjudication for an offense that isn't criminal by statute.
In the linagliptin clinical trial program, adjudication of hospitalization for CHF was implemented during phase 3b.
Dr. Patel has received consultation funds from Kai Pharmaceuticals, Abbott Laboratories, and received research funding from Amgen, Eli Lilly & Co., and Daiichi Sankyo for clinical trial event adjudication activities.
JPAD was a prospective, nonblinded, randomized clinical trial; event adjudication was done by an independent end point committee blinded to treatment assignment.
In contrast to most previous trials, the adjudication comprised all possible non-CV and CV events.
CATCH is a Phase III, multinational, concealed, randomised, active-controlled, open-label trial with blinded adjudication assessing the efficacy and safety of long-term (6 months) tinzaparin therapy versus anticoagulation with warfarin for the treatment of VTE in cancer patients.
3 25262727 Several trials lacked independent adjudication of events, therefore bias in either direction cannot be excluded, including bias towards the null owing to non-differential misclassification of events or assessor bias in trials without independent adjudication.
4 23 Nevertheless, the analysis restricted to trials with independent adjudication of events supported the robustness of our main analysis (see web extra appendix 2).
Few details are available regarding how the adverse events were identified or defined in individual trials, and whether adjudication took place for any of these events.
