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In this clinical trial, adherence to nevirapine prophylaxis in infants was assessed by maternal verbal reports.
In order to maximise the trial adherence subsequent trial medication will be administered in the patient's home by trial personnel.
In addition to potential bias from intervals with unknown adherence, the choice of summary measure used to report trial adherence can provide a misleading estimate of product use.
As our results demonstrate, reporting the median, either per-visit or per-participant, to summarise trial adherence can obscure a large number of subjects with poor adherence.
In the PENTA 11 trial, adherence to ART and acceptability of PTIs was measured routinely, and this paper presents findings from analyses of these data.
At the end of the CAPRISA 004 trial, adherence levels achieved using the ASP approach were compared to those attained pre-ASP.
Similar(47)
Strengths of WHIMS-Y include balance in baseline risk factors between treatment groups, standardized and masked data collection, and high rates of retention and on-trial adherence and exposure.
Compliance with the above procedures was checked via written logs of nutritional intake, and participants were asked to replicate nutritional practices for subsequent trials (adherence = 100%).
In recent PrEP trials, adherence rates approached only 70% [ 25, 26].
In the ideal world of RCT trials, adherence to randomization condition occurs more smoothly.
As is common in randomized controlled trials, adherence was good and showed little variability (see Waller, 2009).
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