Exact(8)
Information was pooled for the number of patients in each trial achieving at least 50% pain relief, or similar measure, for both topical NSAID and control.
The PREV-IX_BOOST study (see online supplementary appendix for a brief description) depends on this trial achieving 7-month follow-up on ∼300 infants.
As has been illustrated in adults, even in the context of a clinical trial, achieving target drug concentrations is challenging, especially early after transplant [ 40].
Other CVD risk factors were treated aggressively and equally in both groups, with the trial achieving excellent blood pressure control, high levels of aspirin and statin usage, and a high degree of smoking cessation (12).
For example, termination in clinical development can be due to business decisions on the part of pharmaceutical companies or to regulatory issues such as a trial achieving efficacy but not surpassing current standards of care.
We calculated the number of patients in each treatment group in each trial achieving various Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) thresholds of pain relief over baseline of ⩾15% (minimal benefit), ⩾30% (moderate), ⩾50% (substantial) 27 and ⩾70% which we defined as extensive improvement.
Similar(52)
Some volunteers in the US Phase 1 clinical trial achieved AMA1 antibody levels that partially blocked P. falciparum invasion of erythrocytes; however, the majority of volunteers displayed low antibody levels with little or no in vitro inhibition of parasite invasion [16].
Criteria: primary end point of the trial achieves statistical significance.
Our trial achieved response and disease control rates of 55.6 and 91.7 %, respectively.
Our trial achieved results at least comparable with the more targeted interventions based in general practice.
Hence the NNIPPS trial achieved the power necessary to detect the hypothesized drug effect.
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