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There is limited data regarding clinical experiences with nintedanib in the real world, in patients who are older, with co-morbidities and who may not fit the stringent criteria required for clinical trial acceptance.
Trial acceptance was not dependent on disease stage, tumour type, sex or age.
The primary reason given for trial acceptance was altruism (40% 110/275), and for declining, trust in the doctor (28% 12/43).
These reasons for trial acceptance were the same irrespective of disease stage, cancer site, sex and age group (data not shown).
Further work in this area is needed as it has been suggested that these factors may have more of an influence on clinical trial recruitment and that clinical trial acceptance does not appear to be based on a rational model of decision making (Curbow et al, 2006).
The primary reasons (available on the questionnaire) for trial acceptance were altruism (110/275; 40%), followed by trial offered best treatment (50/275; 18%), whereas trust in the doctor (12/43; 28%) and wishing the doctor to choose (6/43; 14%) were main reasons for declining.
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Eventually, the settlement that followed an 11-month trial won acceptance -- even if complaints are still heard.
Eventually, however, though complaints are still heard, the settlement that followed an 11-month trial won acceptance.
The primary outcome of being swabbed for an HIV test, therefore, served as a better marker in this trial for acceptance of HIV testing than completion of the informed consent aspect of the study and thereby receiving an HIV test result.
This protocol describes the first randomised controlled trial of Acceptance and commitment therapy in chronic medication-resistant psychosis with an active comparison condition.
This is a single (rater -blind multi-centrater -blindd controlled trial comparing Acceptance and Commitment Therandomisedan acontrolledarison conditrial Befriending.
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