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In addition, it has been shown conclusively that, during a decremental PEEP trial, a decrease in compliance from a maximum value indicates lung collapse [ 5].
Based on blinded data, mean PRO measures improved during the course of the trial (a decrease in DLQI scores indicates an improvement; an increase in the SF-36 and EQ-5D indicates improvement).
In one randomized controlled trial a decrease in the incidence of VAP was noted in patients receiving probiotics despite the fact that their colonization rates were left unaffected [ 39].
Similar(57)
As in the case of the feeding trial A, the decrease in feed consumption went in parallel with a defect of the air conditioning system in the animal housing facility that led to a temperature of 30 32 °C in the animal rooms for a 1-week period.
In the aborted IS trials, a decrease in brain tissue oxygen tension and a tendency to brain metabolic distress were observed.
For both trials, a decrease in haemoglobin of ≥2 g/dL was used to define the clinically meaningful end point as previously described by us and others.
In a post hoc analysis of four prospective randomized intravascular ultrasound trials, a decrease in LDL cholesterol levels and an increase in HDL cholesterol levels were independent predictors of atheroma regression (20).
A randomized, double-blind, placebo-controlled phase III trial in IPF (CAPACITY 1 trial) demonstrated a decrease in the rate of decline of vital capacity and an increase in progression-free survival time over 52 weeks; however, the primary endpoint of change in the percentage predicted FVC at week 72 was not met [ 56].
Furthermore, an analysis of the standard deviation of biogas and power production throughout the whole trial in comparison to the standard deviation before the trial shows a decrease in standard deviation of 48.5% for biogas production and of 8.7% for power production.
9 15 However, the remaining two trials differed from the above: CIN was defined in one trial as a decrease in eGFR of 25% within 4 days, and in the other as an absolute increase in Scr of at least 0.3 mg/dL or 50% or urine output of <0.5 mL/kg/h (>6 h) within 5 days.
16 17 20 However, the CAT-192 trial showed no change between groups at end of study and the Infliximab trial showed a decrease in values from baseline to end of study.
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