We defined a woman compliant to colposcopy if it was performed within 6 months either from the abnormal, ASC-US+, index Pap Test or the positive hr-HPV triage test for ASC-US.
To explain which measures of accuracy and which statistical methods should be used in studies to assess the value of a new binary test as a replacement test, an add-on test, or a triage test.
However, in order to avoid unnecessary follow-up, as well as overtreatment, a high positive predictive value (PPV) of the triage test is important.
The HPV test PreTect HPV-Proofer, detecting E6/E7 mRNA from the HPV types 16, 18, 31, 33 and 45, is used as triage test together with repeat cytology.
LR+=likelihood ratio for high urgency triage test result, LR−=likelihood ratio for low urgency triage test result.
If high-risk HPV is present, a reflex cytology triage test will be carried out on the same sample followed by another triage test 6 months later, if the reflex cytology triage test shows no abnormalities.
With option (i), the material for the first triage test is only evaluated if the result of the primary test requires a triage test.
The Triage test is a quick reliable method for measuring circulating levels of free PlGF.
Applied to the Triage test set, our official run ranked the first in MAP score.
Our data are consistent with other studies using hrHC2 as a triage test [ 23- 26].
To prevent unnecessary referrals to the gynaecologist, a triage test for hrHPV-positive women is necessary.
