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To quantify a linear trend of duration of sulfonylurea use, we conducted a Wald test for linear trend by assigning the median value to each category of duration of sulfonylurea use and modeling this variable as a continuous variable.
The interpretation of the statistically significant trend of increasing risk estimates with increasing duration of use in some but not all HRT subgroups – in contrast to no significant risk trend of duration of HRT use in aggregate – is not clear.
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The risk of squamous cell carcinoma was significantly increased in long-term (20 or more years) smokers, with an odds ratio of 2.05 (1.29–3.26) and a trend for duration of smoking of borderline significance (P trend=0.05).
The lack of a trend for duration of use – in aggregate – in our study is not congruent with the aggregate findings of the large-scale meta-analysis by the Oxford Group [ 13], in which the pooled risk estimate increased significantly with increasing duration of use of HRT (largely differing from the currently used formulations).
ORR was comparable between patients with standard and high-risk profile, the subgroups (25.8% versus 24.6%), while time-to-event endpoints showed a trend of shorter duration in high-risk patients, including median duration of response (5.6 months versus 8.3 months) and overall survival (9.3 versus 19.0 months).
Analyses of trends for duration of use (Table 3) and dosage, as well as analysis of use of individual statins (Table 4), did not show any effect of statins on overall risk of cancer.
Analyses of trends for duration of use and dosage, as well as individual COX2 inhibitors use did not show significant associations with overall cancer risk (Table 4 and Supplementary information).
The general trend of signal duration for the deep earthquake shows little difference from the general trend of shallow earthquakes and cannot be used to distinguish deep earthquakes from shallow ones.
There was also a trend of shorter duration of surgery having a protective effect on cemented THAs.
One study reported a trend of shorter duration of fever and the possibility of bacteremia compared to the overall group [ 24].
There was a significant trend for duration of use (Ptrend=0.004) with an OR of 0.66 (95% CI 0.51 0.86, P=0.002) for more than 24 months of use.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com