Indeed, Villareal's case is an extreme example of what has become a trend of concerning incidents.
In an assessment of safety profiles for DMARDs and biologic agents in more than 10,000 patients with RA, no unexpected safety signals and no trends of concern were noted compared with data seen during earlier trials and in the early days of TNF-inhibiting therapies [ 92].
"A trend of particular concern is the increase in child recruitment [in the Syrian civil war]," Unicef announced recently.
Russia itself had been an empire with many non-Russian citizens, and the emergence of numerous national elites was a trend of considerable concern to Stalin and his leadership.
"A trend of particular concern is the increase in child recruitment," UNICEF said.
This helps provide the UWA with the necessary information to assess countrywide trends, areas of concern, and avenues for resource allocation.
Although hiring trends were of concern for some previous graduating classes, recent numbers show that unemployment fell by nearly five percent in 2015 for college grads and average medium income rose $3,000.
These trends are of concern given the international emergence of invasive community-onset staphylococcal infections.
Prescribing trends are of concern given that they may include people with mild-to-moderate depression unlikely to respond to such treatment.
The increasing trends are of concern, more so as, since the mid-1980s, the anaemia burden was predicted to improve in India.
Mr. Posner also signaled some trends of global concern.
