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A similar trend of binding energy shift is observed when silicon is doped [30].
The calculations are able to reproduce the observed U-shaped trend of binding free energy as a function of aliphatic chain length.
According to Raghavachari and Rohlfing [10], the behavior of small-sized silicon clusters is frequently correlated with the trend of binding energy per atom as a function of cluster size.
The trend of binding constant of Eos with host was CO-β-CD CA < LO-β-CD CA < CdO-β-CD CA < EO-β-CD CA < PO-β-CD CA < JO-β-CD CA. For EO, partial penetration of the oil molecules from the tail side into the wider rim was observed.
However, the trend in the loss of chaperone activity of α-crystallin does not parallel the trend of binding affinities exhibited by these peptides for this chaperone.
Yet smaller subsets from the individual defect profiles (originating from a single probe sequence motif) show basically the same trend of binding affinities which is, however, superposed by a strong sequence dependent bias.
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The simulation results showed that the trend of receptor ligand binding interactions was same as that of their antiproliferative activities.
Concomitant with C/EBPβ up-regulation by differentiation cocktail, a trend of increased binding was apparent in the DMI condition.
Lectins Maclura pomifera (MPA) and Ulex europaeus (UEA) showed a trend of increased binding to PSA enriched from prostate tissue with increasing tumor aggressiveness.
Setting all levels to 12,000 sites per cell, we found that VEGFf resulted in increased VEGF-VEGFR2 retention by cells with Model 2 but only a small decrease with Model 1. Increasing the levels of VEGFR1 or VEGFR2 resulted in a change in the retention levels but the overall trend of increasing binding with VEGFf for Model 2 only was found.
Moreover, the theoretical binding affinity represents the trend of the experimental binding affinity well, which decreases as the size of the metal cation gets larger or smaller than that of K+[34].
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