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There was a trend for expression of the proteasome C2 subunit protein to fall at insulin concentrations of 30 72 mU/l, and this fall became significant at an insulin concentration of 167 mU/l, when its expression declined by ∼50% compared with ∼5 mU/l (P < 0.01).
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Even so, the trends for expression of TSP-3 and DLA-88 are reversed in these samples.
Additionally, the overall trends for expression in tumors relative to normal osteoblasts were similar in frozen and FFPE samples corroborating the quality of the extracted RNA (Additional file 1).
In the placenta, we observed a similar trend for reduced expression of paternally expressed genes and activation of maternally expressed genes, but this was only statistically significant for Dlk1 (Fig. 1c).
In this preliminary report, SLE patients showed a trend for lower expression of PD-1 and higher expression of PD-L1 in unstimulated peripheral blood mononuclear cells compared with other disease controls.
In all data sets analysed, we observed a consistent trend for HOTAIR expression, or DNAme-based surrogate HOTAIR expression, to be associated preferentially with cisplatin response, although statistical significance was not observed in individual data sets.
Interestingly, analysis of candidate gene expression in the cortex showed that Mecp2−/y-EE mice have reduced expression of syntaxin 1A (Stx1a, 42.8±13.7%,), synaptotagmin (23.6±13.7%) and a trend for diminished expression of synaptophysin (46.5±16.8% p = 0.06), as compared to expression levels of Mecp2+/y-SC (figure 4B).
In the present study, four out of 18 meningiomas and three out of eight grade I meningiomas were positive for hTERT mRNA expression (data not shown), suggesting also a trend for increased expression with histologic grading of meningiomas.
Unlike the effects on SOD2 expression, CoCl2 treatment primarily reduced the expression of SDH after 1 day of glucose culture, with a trend for reduced expression with galactose culture as well.
The difference in expression was significant for the ratio of the transcripts (P = 0.02 and P = 0.01 for cohorts II and III, respectively) and demonstrated a similar trend for higher expression of PTPN22-long isoforms in cohort II and lower expression of PTPN22_v4 in cohort III (P = 1.2 × 10-4) for patients with RA (Table 1).
Fenofibrate increased at 14 weeks the expression of ACO but also of ACS1 and induced a trend for higher expression of FAT, FATP and LPL suggesting a parallel stimulation of pathways for fatty acids uptake, activation and oxidation.
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