However, in the last decade tremendous progresses have been made, providing insights into the molecular and functional architecture of these multi-subunit transcriptional machineries.
Since its discovery in the early 1990s, tremendous progresses have been made in understanding the molecular biology and pathogenesis of PRRSV.
Although tremendous progresses have been made since the discovery of pDCs (Reizis et al. 2011; Swiecki and Colonna 2015), a specific marker for identifying pDCs in paraffin-embedded tissue sections by immunohistochemistry analysis is still lacking.
Tremendous progresses have been made for our understanding of the molecular mechanisms and biological function of mitochondrial apoptotic pathway, leading to potential therapeutic development to target the components of the pathway.
Since the milestone created by Murray et al. in 1993 [6 15], tremendous progresses have been made with regards to the size and shape control for CdSe NCs, and monodisperse products can be obtained with environmental-benign raw materials by fairly facile methods.
These tremendous progresses have not only enhanced our knowledge of how cross-links fine-tune the structure and function of natural heme proteins, but also provided us powerful strategies for design of artificial heme proteins with functionalities beyond those of natural heme proteins.
