21 The phenomenon of multidrug resistance has brought tremendous difficulties to the clinical treatment of infection due to limited therapeutic options.
In the case of rigid structures such as polymeric, silica-based, metal and other nanoparticles, sterilization by filtration may be the only option, however, wide particle distributions and particle sizes closer to 220 nm can result in tremendous difficulty in filtration due to the nominal pore size of standard filtration membranes.
And all of these companies run across tremendous difficulty when it comes to sales.
"We have tremendous difficulty in getting American citizens to apply for, enroll and be qualified in many of our engineering and science areas," said Mark Kamlet, provost at Carnegie Mellon University in Pittsburgh, one of the nation's premier research institutions.
Supporters of the idea acknowledge the tremendous difficulties of trying to translate slippery estimates into a single mathematical factor, difficulties that perhaps help explain why there is little hope of consensus now on climate policy.
To date, ZEN has had tremendous difficulty securing funding.
But we want to tell people not to get sick, because if you do, you'll have tremendous difficulty getting treated by the health system".
And if an egg were to hatch, Mr. Blakeman wrote, Violet would have tremendous difficulty feeding her young.
Also, starting in the summer of 2009, the Iranians began having tremendous difficulty running their centrifuges, the tall, silvery machines that spin at supersonic speed to enrich uranium — and which can explode spectacularly if they become unstable.
