"The property has tremendous bones," Pritzker said.
"They've seen losses from specific load-bearing sites of 1-2% a month," says Fong. "That's a tremendous amount of bone to lose and of calcium to put into the blood stream".
In this regard, it was not only an important, but also an unexpected observation, that the osteoblast-specific antagonism of Wnt signalling achieved through transgenic over-expression of Krm2 has such a tremendous impact on bone formation, thereby causing an osteoporotic phenotype, whose severity exceeds the one observed in Lrp5-deficient mice [11].
Additively manufactured porous implants have recently shown tremendous promise in improving bone regeneration and osseointegration, but, as any conventional implant, are threatened by infection.
Despite the tremendous complexity of the bone regulatory system and its fragmentary understanding, we obtain surprisingly good correlations between the model simulations and the experimental observations extracted from the literature.
Particularly, the discrete expression of PiT1 in a subset of hypertrophic chondrocytes late in development [20], its weak expression in osteoblasts and VSMCs [21] together with its low transport capacity [22] make it an unlikely candidate to face the tremendous Pi needs for bone or vascular calcification.
They provide tremendous therapeutic potential for bone marrow transplantation in the treatment of hematologic malignancy, inherited blood disorders, and cancer chemotherapy.
Although BMPs have tremendous potential for inducing bone growth, they have a short half-life (approximately six minutes in non-human primates), and their rapid clearance from the site of application continues to drive the need to find an optimal delivery system.
One of tremendous use of HA is bone grafting application via coating metallic dental implant surface, which stimulates bone healing and therefore improves implant integration rate and strength (Cook et al. 1987; Lange and Donath 1989).
Racehorses running long distances at high speeds exhibited tremendous changes within the subchondral bone in the carpal and metacarpophalangeal joints, including osteochondral fragmentation and fracture, subchondral bone necrosis and sclerosis [ 69, 70].
