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Causes for chemotherapy failure in cancer treatment reside in multiple levels: poor vascularization, hypoxia, intratumoral high interstitial fluid pressure, and phenotypic resistance to drug-induced toxicity through upregulated xenobiotic metabolism or DNA repair mechanisms and silencing of apoptotic pathways.
Causes for chemotherapy failure in cancer treatment reside in multiple levels: poor vascularization, hypoxia, intratumoral high interstitial fluid pressure, and phenotypic resistance to drug-induced toxicity through up regulated xenobiotic metabolism or DNA repair mechanisms and silencing of apoptotic pathways [ 1- 5].
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Indeed, the main challenge posed by current treatments resides in their delayed onset of action, the therapeutic improvement being observable only after 4 to 8 weeks of continuous administration [6] [8].
Therefore, it is possible that candidates for targets of migraine treatment may reside outside the BBB; the dural vasculature, the trigeminal ganglion (TG) and in CNS regions lacking a BBB such as pituitary and pineal glands [15] and at nerve afferents that connect to the TG.
To a certain extent, the efficacy of RA in cancer treatment may reside in its ability to also modulate the function of immune effectors.
The distribution of outcome results for placebo and active treatment groups reside along the line of unity over a placebo mortality range between 20%and60%0%.
Table S6 contains a list of genes differentially expressed in association with host treatment that reside within an oviposition QTL significant at the genome-wide level (Pannebakker et al. 2011).
The length of time for the survival rate to plateau in breast cancer might indicate the involvement of a cell type capable of disease recurrence which is able to withstand primary treatment and reside in the body, often undetected, for prolonged periods.
Those randomized into the treatment group resided in the Youthful Offender Unit (YOU).
To describe the principles upon which present day cataract treatment success resides.
Patients/caretakers were considered eligible for interview if they were aged 16 years or over, had come to the facility for treatment, normally resided in the local area, had lived there for at least 6 months, and if this was their nearest government health facility.
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