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The procedure follows the intention to treat (ITT) principle, that is, based on the initial treatment intent, not on the treatment eventually administered.
Inclusion criteria were as follows: inoperable primary tumor, curative treatment intent, and no distant metastases.
The number of biopsy cores (both positive and total), treatment intent (curative or non-curative), results of imaging for metastasis staging, and final treatment were recorded.
Palliative or non-curative treatment intent was defined as patients with no further active treatment options available, but those that could be on phase 1 trials or be receiving treatment to control or maintain disease stability but without curative intent.
Treatment intent (i.e. neo/adjuvant or palliative) was also recorded for all patients with breast or colorectal cancer.
Treatment intent (curative or palliative) did not affect study participation.
All these patients had a palliative treatment intent, which was not modified by PET/CT.
Treatment intent was curative (including adjuvant) in 38%, palliative in 49% and don't know in 8%.
19 No information was available about treatment intent nor about comorbidity status.
We examined impact according to age, PS, comorbidity and treatment intent.
The implications of a neutropenic event for further chemotherapy depend very much on the treatment intent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com