It includes the initiation of the treatment, implementation of the prescribed regime, and discontinuation of the pharmacotherapy [ 8].
The concept of empowerment includes interdisciplinary planning and documentation of treatment, implementation of milieu therapy, strict application of the concept of informed consent and a policy of avoiding restraint, as for example by unlocked doors of all wards.
If further validated in other settings, it will provide a framework that can be used to conduct observational studies of large numbers of patients in order to examine factors that influence patient outcomes, such as new treatments, implementation of practice guidelines, quality of care, and practice variation.
Some relevant potential threats to the statistical conclusion validity of our study could be: low statistical power, unreliability of measures and unreliability of treatment implementation [ 24].
In the "reliability of treatment implementation", we have to consider that a participant who could have used visualization may have completely disregarded the views of the visualization tool.
In general, turnover among mental health service providers is high, typically between 25 50 % per year, which, although detrimental for treatment access, implementation of evidence-based treatments, and quality of care, provides opportunities to restructure treatment program staffing relatively rapidly [ 39– 46].
Further details of the treatment implementation are outlined below.
Urquhart et al. and more recently Vrijens et al. argued that three phases of chronic drug treatment can be identified: acceptance of the treatment plan, implementation of the drug regimen and eventually complete discontinuation (non-persistence) of treatment [ 7, 8].
Prehospital personnel can potentially impact outcomes in sepsis through early identification and treatment implementations, improving processes of care and transition of care.
The combination of early clinical recognition and predictive scores could help in the detection of patients at-risk and in the early treatment or implementation of preventive strategies.
Advances in knowledge of mechanisms, treatment and implementation of prevention and detection strategies are current priorities.
