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We have previously described the treatment grouping in detail [ 18].
Graders were blinded from the treatment grouping to eliminate observer bias.
The person performing the analyses will remain blind to the treatment grouping.
Performing k-means clustering of the treatments to obtain 5 clusters results in the exact same treatment grouping as obtained through hierarchical clustering with Ward's linkage.
To account for treatment regimes, patients were grouped according to the drug regimen (synthetic DMARD monotherapy: MTX, LEF or sulfasalazine; TNFi monotherapy: adalimumab or etanercept; TNFi combination therapy with a synthetic DMARD: adalimumab, etanercept, or infliximab plus MTX), and the treatment grouping variable was included in the model.
Similar(55)
treatment group.
Treatment group > Control group n.s.s
They constitute my treatment group.
There are two treatment groups.
Morbidity among treatment groups varies.
No deaths occurred in either treatment group.
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