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We analyzed daily and 2-week dosing frequencies to compare changes in treatment dynamics at reduced frequencies.
Though it is known that sufficient exposure of bacteria to antibiotics is key to effective TB treatment, dynamics of antibiotics and Mtb at sites of infection, i.e. within granulomas, remain largely unknown and difficult to assess.
Pharmacokinetic parameters have large influences on antibiotic exposure in granulomas for both dosing frequencies; clearance of RIF and INH from the peripheral compartment is correlated with many facets of treatment dynamics (Tables 1 and 2).
Previous mathematical modeling work has argued that the basic dynamics of HIV infection, including the growth properties in the acute phase of the dynamics, the overall equilibrium properties, and basic drug treatment dynamics, are not altered by the occurrence of coinfection [ 28, 30].
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Most existing studies on parking fall short in reproducing the dynamic spatiotemporal features of traffic congestion in general, lack the treatment of dynamics of the cruising-for-parking phenomenon, or require detailed input data that are typically costly and difficult to collect.
Fluid inertial forces are isolated and combined with body inertial terms to ensure robust treatment of dynamics for bodies of arbitrary mass.
Fractional calculus is one of the most swiftly growing areas in mathematics, and during recent years, researchers have been trying to use it in the treatment of dynamics of complex systems [22, 25].
With no acquisition bias, treatment frequency dynamics would be dominated by the loss-process, which favours effective cures due to the abandonment of ineffective treatments.
Here, in simple terms, treatment frequency dynamics are typically dominated by two processes, representing the rates of acquisition and loss of remedies.
Whereas solvent effects are taken into account implicitly in the ground- and excited-state wave functions, a proper treatment of dynamics, explicit solvent molecules, counterions, or even aggregation of the dyes in various networks is potentially required and would necessitate further methodological developments.
The purpose of this review was to detail the segmentation techniques available for each of these peripheral CT and MRI modalities and to describe advances in segmentation methods as applied to study longitudinal changes and treatment-related dynamics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com