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The purpose of this study was to examine the anatomical and behavioural sequelae in the normal brain associated with tactile stimulation treatment during development.
In contrast to the lack of specific action on biochemical indices of synaptic outgrowth, neonatal dexamethasone did cause alterations in norepinephrine synthesis and turnover in both central and peripheral sympathetic neurons which could contribute to the physiological and behavioral abnormalities associated with glucocorticoid treatment during development.
The drug treatment during development caused no visible alterations in sexual differentiation of the flies (data not shown).
Interestingly, we found an inverse correlation between the length of Dox treatment during development and the efficiency of Ptet-controlled reporter gene expression after Dox withdrawal.
Moreover, developmental exposure followed by adult rechallenge unmasked silent toxicity apparently produced by MB treatment during development: although no changes were seen in response to developmental-only MB exposure, reductions did occur when it was followed by adult rechallenge with MB.
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The present study shows that it is possible to simultaneously remove two vertically transmitted rhabdoviruses from a strain of L. salmonis by subjecting the lice to two dsRNA treatments during development.
Altering the treatment time during development revealed a critical chemical treatment window for correcting the aorta phenotype to be between 12 and 24 hpf.
Differential sensitivity of tachykinin vs enkephalin gene expression in the posterior striatum in response to acute p-chloroamphetamine treatment during postnatal development.
Our previous studies showed that binge-pattern ethanol (EtOH) treatment during pubertal development negatively dysregulated the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis, as manifested by alterations in corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP), and corticosterone (CORT) during this time period.
This effect was significantly lessened by PJ treatment during the development of sensitization.
The inbred BALB/cCrgl strain was used because it has a low mammary tumor incidence and its response to E2 treatment during neonatal development is well documented.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com