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These include a fear of treatment, divergence between local and biomedical understandings of NTDs, insufficient and inadequate health education, migration patterns, ineffective systems of drug distribution and the changing political and economic context in which MDA occurs.
At 3 years from treatment divergence (which was about 5 years after the initiation of endocrine therapy), the group who converted the therapy to AI showed an absolute 3.1% recurrence and an absolute 0.7% reduction in breast cancer mortality.
At 6 years from treatment divergence (that is, 8 to 9 years from allocation to endocrine treatment), AI therapy was associated with an absolute 3.5% (SE 1.1%) decrease in BC recurrence (12.6% versus 16.1%, relative decrease 29% [SE 6%], P < 0.00001).
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We observed treatment-specific divergence among all three treatment groups; data points from tumors treated with 10 mg/kg nal-IRI were clustered around the smallest changes in both tumor volume and FAZA uptake (blue ellipsoid), while data points from tumors treated with 50 mg/kg irinotecan were clustered around the largest changes (gray ellipsoid).
A method for linear reconstruction of staggered vector fields with special treatment of the divergence is presented.
Besides the designed accuracy, numerical experiments also demonstrate improved stability of the proposed methods over the base central discontinuous Galerkin methods without any divergence treatment.
Within 1 day of storage, 1-MCP treatment caused transcriptomic divergence from untreated control fruit, indicating early expression changes in the apple transcriptome provoked by this treatment.
The pH treatment dependent phenotypic divergence was also reflected in the relationship between pond pH and larval period: the correlation was stronger at pH 7.5 (log b ± S.E. = -0.09 ± 0.01, P < 0.001) than at pH 4.3 (log b ± S.E. = -0.06 ± 0.01, P < 0.001; Figure 2C).
A significant and positive correlation between read length and variant call accuracy was also demonstrated for both SNPs and indels in high divergence treatments, and for SNPs in low divergence treatments, although the impact of this relationship was relatively small (Table 2).
Moreover, most normalization methods were developed for comparisons between treatments with expression divergence at only a few genes [33].
Since the phenotypes we competed were rather similar, this effect may have delayed the response in our divergence treatments.
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