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For many, a diagnosis of Alzheimer's disease can mean life in a dreary nursing home and a treatment centered on powerful antipsychotics to combat the onset of memory loss, dementia and other signs of a mind that is slowly unraveling.
The concordant changes observed in response to combined treatment centered on metabolites intimately associated with the TCA cycle, some amino acids and other metabolites.
The severity of the yeast respiratory phenotypes partly correlated with the different clinical presentations observed in MTO1 mutant patients, although the clinical outcome was highly variable in patients with the same mutation and seemed also to depend on timely start of pharmacological treatment, centered on the control of lactic acidosis by dichloroacetate.
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