Industry-standard light emitting diodes (LEDs) were used to produce the light, with arrays of emitters arranged in a series of treatment arrays to cover the target area of the alveolus of both the maxilla and mandible.
A headset similar to an eyeglass support structure to be worn by the patient on a daily or weekly basis, with attachment and adjustment mechanisms to position the treatment arrays in the appropriate location for the given patient (Figure 1C).
The device monitors and records patient compliance by operating the treatment arrays only when the device is worn by the patient, and the investigator can obtain compliance data at each patient visit.
(C) A headset similar to an eyeglass support structure to be worn by the patient on a daily or weekly basis, with attachment and adjustment mechanisms to position the treatment arrays in the appropriate location for the given patient.
A set of four extra-oral treatment arrays, each with a flexible printed circuit board and a set of LEDs mounted on a contoured heat sink and infrared-transmissible plastic lens, with conductive cables to the controller (Figure 1A,B).
(A, B) A set of four extra-oral treatment arrays, each with a flexible printed circuit board and a set of LEDs mounted on a contoured heat sink and infrared-transmissible plastic lens, with conductive cables to the controller.
It can be clearly seen that the second eigengene mainly represents the differences in gene expression between control (1 to 4) and treatment arrays (5 to 18).
For the treatment arrays, cyanine-5′-UTP-labelled RNA from a cell line treated with 100 n M of MEK162 for 24 h was compared with cyanin-3′-labelled RNA from control cells on a single array.
There was minimal variability between duplicate control or treatment arrays, however, in our statistical analysis duplicates were not averaged because this could not be done for the AMPH groups.
