However, decision-makers often deviate from CEA results because other principles such as equal treatment and priority to the worst-off [ 6- 8] and other factors like feasibility or acceptability influence decisions, as well [ 9- 11].
Down syndrome patients are not explicitly listed in the groups of patients at increased risk for influenza, so early antiviral drug treatment and priority vaccination are prescribed for Down syndrome patients only if a high-risk health condition is found, for example, a cardiovascular disease or if persons with Down syndrome are considered to have a cognitive disorder (2 ).
In light of the detrimental effect of poor mental health on physical wellbeing, and the increased complexity generated by multiple chronic conditions, clear communication about symptoms, diagnoses, treatment and priorities is of utmost clinical importance.
This new understanding of FM by severity level is very important for the evaluation of FM treatments and priority setting in health care, for example by providing input data for the evaluation of medical resource utilization, costs and quality of life adjustments in the health economic evaluation of alternative FM treatments.
Additionally, participants will be invited to participate in individual interviews assessing patient experience with treatment, preferences for treatment approaches, and priorities for treatment outcomes.
As a discipline, the appraisal of evidence by HTA bodies can reflect many factors, including the relevant clinical and economic evidence considered, national and regional differences in drug costs, currently available treatments, and priorities and values of the populations affected.
Although the clinical evidence base is just one factor taken into consideration in the HTA decision-making process (others being national and regional differences in drug costs, currently available treatments, and priorities and values of the populations affected), 4, 5, 10– 12 the clinical evidence base is a key building block that is relevant and transferable across all geographies.
There is a clear consensus across the four groups that one of the most important considerations is what will happen to the patient without treatment, and so priority is given to those with a poor prognosis.
Intervention: GPs allocated to this group will receive a multifaceted educational intervention on performing a narrative doctor-patient dialogue reflecting treatment targets and priorities of the patient and on performing a narrative patient-centred medication review.
GPs allocated to the intervention arm will receive an educational intervention: (1) on performing a narrative doctor-patient-dialogue reflecting treatment targets and priorities of the patient, and (2) on performing a narrative patient-centred medication review.
Understanding the factors involved in the demand for orthodontic treatment in a particular population enables a better planning of resources as well as a better assessment of treatment needs and priorities [ 2, 3, 7].
