In an attempt to define the role of HAE in the treatment algorithm of such patients, we present the complications, clinical outcome and the quality-of-life assessment in 20 consecutive patients who were treated with HAE over a time span of 17 years.
An equally important priority would be to establish and adapt appropriate community-level interventions (Patel et al. 2010) making use of community human resources to increase access to treatment and to evaluate user-friendly treatment and referral algorithms such as those recently published by the World Health Organization World Health Organizationn 2010).
Such treatment algorithms stand in contrast to the personalized medicine approach, in which biomarkers would guide decision making.
9 Not only have such treatment algorithms changed in recent years to recommend GLP-1 agonists earlier, but package labeling is also changing to expand their use.
The trials provide a model for designing response-guided treatment algorithms in other malignancies, such as lung, head and neck and ovarian cancer, for which induction treatment has a potential role and the algorithms need to be addressed in randomized phase III trials.
A potential weakness of the study is that it is retrospective in nature, and thus factors such as treatment algorithms, including various surgical techniques, chemotherapy protocols, and radiation approaches, may be confounded.
Current LN treatment algorithms are based on combinations of non-selective immunosuppressants such as steroids plus CYC, MMF or AZA [ 4, 5].
Nevertheless, there are limited but increasing reports of concomitant metronidazole and carbapenem resistance (14 ), and such resistance poses a threat to current treatment algorithms.
Clinicopathological parameters and immunohistochemical markers are combined in guidelines such as St Gallen's consensus and Nottingham [ 4] prognostic Index or incorporated in internet algorithms such as Adjuvant!Online (https://www.adjuvantonline.com/index.jsp), for treatment decision making.
Because syndromic management is not based on a proven diagnosis, such population based data is needed to inform local treatment algorithms.
