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For example, desire for action may lead to treating resistance as mere obstacle and not as a moment for reflection.
MicroRNAs will soon be employed in treating resistance to EGFR-TKIs in cancers.
Several IGF1R inhibitors are in clinical development (e.g. monoclonal antibodies CP-751,871, IMC-A12, AMG-479 and MK-0646) and it has been suggested that these agents may be particularly effective at reversing or treating resistance to chemotherapeutic or targeted breast cancer treatment.
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Hume also treats resistance in his footnote to the EHU, Section 7.1.15.
The synergistic combination of BJ and antibiotics could be used to prevent or treat resistance.
These results combined suggest that HIF-1 is involved in both de novo and acquired AI resistance and, therefore, could be therapeutically targeted to prevent and treat resistance to letrozole and the other AIs.
Ethambutol (EMB) is an antituberculosis drug that is widely used for treating drug resistance, and it is also commonly used for treating multidrug-resistant tuberculosis [ 1].
To date, no study has assessed the potential interactions between these 2 interventions in treating insulin resistance.
The combination of a chemotherapeutic drug with a P-glycoprotein (P-gp) inhibitor has emerged as a promising strategy for treating multidrug resistance (MDR) cancer.
In some cases drugs, such as the diabetes drug metformin, may prove useful: metformin enhances insulin sensitivity, and has a potential role in treating insulin resistance in addition to diabetes.
Inhibiting miR-181a might be a potential new strategy for treating insulin resistance and T2D [ 96].
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