Exact(57)
TEs are generally classified according to their transposition mechanism.
Although we have shown the evidence of past mobility of the CMITE-IN element, the transposition mechanism remains unclear.
Since CMITE-IN and MSITE share similar TE structure, we speculate that the transposition mechanism of CMITE-IN may be also very similar to that of MSITE.
Transposable elements are usually classified in two major groups based on their structure and transposition mechanism: Retrotransposons or class I elements, which transpose by an RNA intermediate, and class II or DNA transposons, which use an intermediate of DNA.
This transposition mechanism involves the binding of the transposase to the element TIRs and the excision of the element generating a DSB at the donor site followed by the integration of the element into a different chromosomal site.
The only class II elements that transpose by a different mechanism are Helitrons and related elements, that transpose by rolling-circle replication, Mavericks, whose transposition mechanism is not yet known [14], and the bacterial IS200/605 family of insertion sequences that transpose as a single stranded transposon circle [15], [16].
Alternatively, LCIs could originate from a low frequency transposition mechanism.
However, the transposition mechanism seems to be different [ 20].
Similar(3)
Their further study should enrich our understanding of infection and disease processes, the diversity of transposition mechanisms and regulation, and of genome evolution.
Transposases catalyze the transposition mechanisms of mobile genetic elements.
In this work each element presents a different behavior probably due to their distinct transposition mechanisms.
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